Pneumococcal Vaccine Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Type (Conjugate Vaccines, Polysaccharide Vaccines), By Indication (Bronchitis, Meningitis, Pneumonia, Sepsis), By Product (Pneumovax23, Prevnar 13, Synflorix), By Distribution (Government Authorities, Non-Governmental Organizations), By Region & Competition, 2020-2030F

Market Overview

Global Pneumococcal Vaccine Market was valued at USD 9.63 billion in 2024 and is anticipated to project impressive growth in the forecast period with a CAGR of 6.26% through 2030. The global pneumococcal vaccine market is a crucial segment of the pharmaceutical and healthcare industry, primarily aimed at preventing infections caused by Streptococcus pneumoniae bacteria. Pneumococcal infections can lead to various illnesses, including pneumonia, meningitis, and sepsis, and they pose a significant public health threat, particularly to young children and the elderly. For instance, according to WHO estimates in 2023, pneumococcal infections cause approximately 1.6 million deaths worldwide each year, with nearly one million fatalities occurring in children under the age of five. Given its significant impact on child mortality, WHO classifies pneumococcal disease as a high-priority condition for vaccination. To combat this, the organization strongly recommends the use of 13-valent pneumococcal conjugate vaccines (PCVs) as an effective preventive measure. These vaccines play a crucial role in reducing severe infections such as pneumonia, meningitis, and sepsis in young children, particularly in regions with limited healthcare access and high disease prevalence.

Key Market Drivers

Rising Global Awareness of Pneumococcal Diseases

One of the fundamental reasons behind the growth of the pneumococcal vaccine market is the increasing understanding of the serious health consequences posed by pneumococcal diseases. Medical professionals, policymakers, and the general public are becoming more aware of the debilitating and potentially fatal nature of these infections, leading to a heightened sense of urgency in preventing them. For instance, in June 2023, Sanofi and SK bioscience announced positive results from phase II clinical trials of their 21-valent conjugate vaccine candidate. The findings suggest that GBP410 may provide broader serotype coverage compared to existing vaccines, potentially expanding its market share. Based on these promising results, the companies plan to advance to phase III trials in 2024, with the goal of obtaining final data by 2027.

Public health organizations and advocacy groups have played a pivotal role in disseminating information about pneumococcal diseases. Their efforts include educational campaigns, public service announcements, and initiatives that emphasize the importance of vaccination. As individuals become better informed, they are more likely to seek out and request pneumococcal vaccines.

Governments worldwide are increasingly recognizing the public health burden associated with pneumococcal diseases. In response, many countries have implemented vaccination programs as part of their broader healthcare strategies. These government-led initiatives often involve funding and subsidies, making vaccines more accessible to a wider population.

The growing awareness of pneumococcal diseases has facilitated greater collaboration among healthcare providers, pharmaceutical companies, and research institutions. These collaborations aim to improve vaccine research, development, and distribution. Pharmaceutical companies are increasingly motivated to invest in the production of pneumococcal vaccines, driven by the growing global demand.

Awareness of the broad range of individuals susceptible to pneumococcal diseases has led to the expansion of target populations for vaccination. While initially focused on infants and children, vaccination programs now often include older adults and individuals with specific health conditions, broadening the market for pneumococcal vaccines.

One of the most compelling drivers of awareness is the tangible reduction in disease burden seen in regions with effective pneumococcal vaccination programs. The decrease in pneumococcal infections, hospitalizations, and deaths is a testament to the efficacy of these vaccines and reinforces the importance of vaccination.

The ongoing COVID-19 pandemic has underscored the significance of vaccinations in protecting global health. This heightened awareness of vaccine-preventable diseases, coupled with the increased vaccine manufacturing capacity developed during the pandemic, has positioned pneumococcal vaccines as a crucial component of pandemic preparedness.

Expansive Immunization Programs

One of the primary ways in which expansive immunization programs contribute to market growth is by making pneumococcal vaccines widely accessible. Governments often procure vaccines in large quantities and distribute them through public health systems, ensuring that even remote or underserved populations have access to vaccination. According to an NCBI article published in March 2022, the U.S. Department of Health and Human Services has set goals under the Healthy People 2030 initiative to enhance vaccination rates among adults aged 19 and older. A key focus is increasing pneumococcal vaccine uptake due to its critical role in disease prevention. The initiative aims to exceed a 90% vaccination rate for vaccines recommended by the Advisory Committee on Immunization Practices (ACIP).

Also, in November 2022, the University of Liverpool launched a spin-out company, ReNewVax Ltd, to develop next-generation pneumococcal vaccines. The company focuses on the rational design of vaccine candidates to combat complex bacterial infections. Backed by Innovate UK seed funding and the University of Liverpool's Enterprise Investment Fund, ReNewVax aims to create safe, cost-effective, and easily manufacturable vaccines. Its lead program is dedicated to targeting Streptococcus pneumoniae, addressing a critical need for improved prevention strategies against pneumococcal diseases.

Many countries have made pneumococcal vaccination mandatory as part of their national immunization schedules. This requirement ensures a high vaccination rate, as children are routinely vaccinated against pneumococcal diseases. Such mandates lead to a consistent demand for vaccines, driving market growth.

Expansive immunization programs aim to achieve high vaccine coverage rates within specific target populations, often infants and young children. This expanded coverage directly translates into a substantial increase in the demand for pneumococcal vaccines.

Governments recognize the cost-effectiveness of vaccination programs and are willing to allocate significant resources to support them. This financial backing, in the form of subsidies, grants, and funding, helps reduce the economic burden on healthcare systems and drives the growth of the pneumococcal vaccine market.

In addition to children, immunization programs are increasingly including older adults and individuals with specific medical conditions as target groups for pneumococcal vaccination. This broadening of the target population creates a more extensive market for pneumococcal vaccines.

Expansive immunization programs also contribute to heightened public awareness of pneumococcal diseases and the importance of vaccination. As more people become informed about the potential risks of these infections, they are more likely to seek out and support vaccination efforts, further stimulating market growth.

Successful immunization programs lead to a tangible reduction in the incidence of pneumococcal diseases, hospitalizations, and associated healthcare costs. The decreased disease burden not only improves public health outcomes but also reinforces the value of vaccination, fostering continued demand for pneumococcal vaccines.

Pharmaceutical Innovation

Pharmaceutical innovation has led to the development of advanced pneumococcal vaccine formulations. Pneumococcal conjugate vaccines (PCVs) are notable examples of this progress. These vaccines are more effective, especially in children, as they provide protection against a broader spectrum of pneumococcal strains. As new PCV formulations are introduced, they create opportunities for growth within the pneumococcal vaccine market.

Innovations in vaccine production techniques have improved the safety profiles of pneumococcal vaccines. Pharmaceutical companies are continually refining vaccine manufacturing processes to reduce adverse effects, making vaccines more palatable to both healthcare providers and patients. This enhanced safety fosters trust and increases vaccine adoption rates.

Pharmaceutical innovation has expanded the age groups for pneumococcal vaccination. Initially targeting infants and young children, recent innovations have led to vaccines designed for older adults and individuals with specific health conditions. This diversification of target populations broadens the market for pneumococcal vaccines.

Pharmaceutical companies are responding to the rise of antibiotic-resistant strains of Streptococcus pneumoniae through innovative vaccine development. The ability of pneumococcal vaccines to prevent infections reduces the overuse of antibiotics, thus mitigating the development of antibiotic resistance—a pressing global health concern.

Pharmaceutical innovation is propelling the creation of next-generation pneumococcal vaccines. These vaccines incorporate advancements in biotechnology and molecular biology, enabling a more targeted and robust immune response. As these next-gen vaccines are introduced to the market, they stimulate growth through improved efficacy and broader applicability.

Profound Impact on Public Health

One of the most significant ways pneumococcal vaccines impact public health is by reducing the incidence of pneumococcal diseases. As vaccination rates rise, the number of people contracting pneumonia, meningitis, and sepsis caused by pneumococcus diminishes. This decrease not only improves individual health but also alleviates the strain on healthcare systems, lowering healthcare costs.

Vaccination against pneumococcal diseases has led to a marked reduction in hospitalizations. Fewer people require intensive medical care and hospital stays due to these infections, freeing up healthcare resources for other critical needs. The resulting reduction in hospitalization rates underscores the value of pneumococcal vaccines and contributes to their sustained demand.

Perhaps the most compelling aspect of pneumococcal vaccines is their role in lowering mortality rates. Vaccination has saved countless lives, particularly among children and the elderly who are most vulnerable to pneumococcal diseases. This life-saving impact reinforces the importance of vaccination and encourages further adoption, fostering market growth.

The profound public health impact of pneumococcal vaccines extends beyond individual health. Improved public health outcomes mean healthier communities, increased workforce productivity, and a better quality of life. As the positive effects of vaccination become evident, individuals and healthcare systems are more inclined to prioritize pneumococcal vaccination, driving market growth.

The success of pneumococcal vaccines in reducing disease burden and improving public health outcomes builds trust in vaccination programs. People are more likely to accept vaccines when they witness their effectiveness firsthand. This trust reinforces vaccination initiatives, ensuring sustained demand for pneumococcal vaccines.

Governments and healthcare systems prioritize pneumococcal vaccination due to its profound impact on public health. Recognizing the cost-effectiveness of vaccination compared to treating pneumococcal diseases, policymakers allocate resources and support vaccination programs. This prioritization bolsters the growth of the pneumococcal vaccine market.

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Key Market Challenges

Economic Disparities

One of the most prominent challenges is the economic disparity among nations. High-income countries often have better access to pneumococcal vaccines due to robust healthcare infrastructures and funding. In contrast, low- and middle-income countries struggle to afford these vaccines, leading to unequal access and health disparities.

Antibiotic Resistance

The emergence of antibiotic-resistant pneumococcal strains is a global health concern. While vaccination reduces the need for antibiotics, further research and development are required to address evolving resistance patterns.

Supply Chain and Distribution

Ensuring the efficient distribution and storage of vaccines, especially in remote and underserved areas, poses logistical challenges. Maintaining the cold chain for vaccines can be difficult, leading to issues with vaccine efficacy and wastage.

Evolving Serotypes

Streptococcus pneumoniae is known for its capacity to evolve and develop new serotypes, some of which may not be covered by existing vaccines. Keeping pace with the ever-changing pneumococcal landscape requires continuous vaccine development and updates.

Key Market Trends

Next-Generation Vaccines

Advancements in vaccine technology are paving the way for next-generation pneumococcal vaccines. These vaccines are designed to offer broader protection against a wider range of pneumococcal serotypes. By harnessing innovative formulations and targeting evolving bacterial strains, next-gen vaccines are poised to enhance vaccine effectiveness and durability.

Combination Vaccines

Combination vaccines that protect against multiple diseases are gaining traction. Pneumococcal vaccines integrated with vaccines against other infectious agents can streamline immunization schedules and increase overall vaccine coverage. This trend enhances convenience and reduces the number of required shots for patients.

Vaccine Delivery Innovations

Innovations in vaccine delivery systems are set to make vaccination more accessible and efficient. Advances in needle-free technologies, microneedles, and skin patches may revolutionize vaccine administration, particularly in resource-constrained settings where maintaining a cold chain is challenging.

Expanding Market Reach

Global initiatives and partnerships are working toward expanding the reach of pneumococcal vaccines to underserved regions. Organizations like Gavi, the Vaccine Alliance, are actively promoting equitable access to vaccines, helping reach vulnerable populations and reducing global health disparities.

Segmental Insights

Distribution Insights

Non-Governmental Organizations (NGOs) was poised to emerge as a prominent distribution channel in the Global Pneumococcal Vaccine Market in the forecast period for several compelling reasons. Firstly, NGOs often have well-established networks and infrastructure in regions where access to healthcare resources may be limited, making them invaluable partners in reaching underserved populations. Secondly, their presence is often driven by a strong commitment to public health, which aligns with the broader mission of ensuring vaccine accessibility to all, especially in developing regions. NGOs are known for their agility and ability to quickly respond to health crises, making them ideal partners for vaccine distribution during emergencies or outbreaks. Lastly, their reputation for transparency and accountability enhances confidence among donors and stakeholders, further bolstering their role in vaccine distribution efforts. In light of these factors, the rise of NGOs as a distribution channel is expected to be a significant driver of increased vaccine accessibility and market growth in the coming years.

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Regional Insights

Based on region , North America was poised to maintain a substantial market share within the overall market. This is attributable to several key factors, notably the presence of major industry players and a well-established healthcare infrastructure, which collectively underpin its significant market presence. The region's noteworthy investments in pneumococcal vaccine development, coupled with an uptick in pneumonia cases within the studied region, are anticipated to fuel market expansion.

As per the National Foundation for Infectious Diseases, updated data in March 2022 reveals that pneumococcal pneumonia leads to the hospitalization of approximately 150,000 individuals annually in the United States. This elevated incidence of pneumococcal infection within the region is expected to be a driving force behind market growth. According to the January 2023 update from the CDC, in 2021, 24.0% of adults aged 18 and above in the United States had received a pneumococcal vaccination at some point. Consequently, the projected increase in pneumonia cases is anticipated to spur demand for pneumococcal vaccines in the region, thereby fortifying market growth prospects throughout the forecast period.

The substantial market share held by North America is also attributed to the robust presence of key industry players and a well-developed healthcare infrastructure. Notably, in July 2021, the FDA granted approval for Merck's VAXNEUVANCE (Pneumococcal 15-valent Conjugate Vaccine) for active immunization against invasive diseases caused by multiple Streptococcus pneumoniae serotypes in adults aged 18 years and older. Similarly, Health Canada authorized two new pneumococcal vaccines for adults aged 18 and older, namely Prevnar 20 (PNEU-C-20) in May 2022 and Vaxneuvance (PNEU-C-15) in November 2021. Vaxneuvance also received authorization for infants and children aged 6 months to 17 in July 2022. Consequently, the surge in approvals and the introduction of new pneumococcal vaccine products within the studied region are expected to bolster market expansion throughout the forecast period.

Recent Developments

• In January 2024, Pfizer Inc. secured marketing authorization from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) for its 20-valent pneumococcal conjugate vaccine candidate (20vPnC).
• In January 2023, the U.S. Food and Drug Administration (FDA) initiated a priority review process for Pfizer's supplemental biologics license application, concerning the 20-valent pneumococcal conjugate vaccine candidate (20vPnC). This application pertains to the vaccine's intended use for preventing invasive pneumococcal disease (IPD) caused by the 20 distinct Streptococcus pneumoniae (pneumococcus) serotypes included in the vaccine. It also encompasses the prevention of otitis media resulting from seven of the 20 Streptococcus pneumoniae serotypes contained in the vaccine.
• In October 2023, Vaxcyte, Inc. entered into a new commercial manufacturing agreement with Lonza. Through this collaboration, Vaxcyte aims to enhance its commercial manufacturing capacity for its pneumococcal conjugate vaccine (PCV) candidates.I
• In May 2022, GSK made a significant commitment of USD 3.3 billion towards the acquisition of Affinivax, a clinical-stage vaccine developer. Affinivax has a vaccine candidate in its pipeline that is at the Phase III stage of development. This particular vaccine candidate addresses a more extensive range of bacterial strains compared to any currently available pneumococcal vaccine. 

Key Market Players

• GSK PLC
• Pfizer Inc
• Merck KGaA
• Serum Institute of India Pvt Ltd
• CSL Ltd
• Sanofi SA
• Walvax Biotechnology Co., Ltd
• Beijing Minhai Biotechnology Limited Company
• AstraZeneca PLC
• BioNTech

Report Scope:

In this report, the Global Pneumococcal Vaccine Market has been segmented into the following categories, in addition to the industry trends which have also been detailed below:

• Pneumococcal Vaccine Market, By Type:

o   Conjugate Vaccines

o   Polysaccharide Vaccines

• Pneumococcal Vaccine Market, By Indication:

o   Bronchitis

o   Meningitis

o   Pneumonia

o   Sepsis

• Pneumococcal Vaccine Market, By Product:

o   Pneumovax23

o   Prevnar 13

o   Synflorix

• Pneumococcal Vaccine Market, By Distribution:

o   Government Authorities

o   Non-Governmental Organizations

• Pneumococcal Vaccine Market, By Region:

o   North America

§  United States

§  Canada

§  Mexico

o   Europe

§  Germany

§  United Kingdom

§  France

§  Italy

§  Spain

o   Asia-Pacific

§  China

§  Japan

§  India

§  Australia

§  South Korea

o   South America

§  Brazil

§  Argentina

§  Colombia

o   Middle East & Africa

§  South Africa

§  Saudi Arabia

§  UAE

§  Kuwait

Competitive Landscape

Company Profiles: Detailed analysis of the major companies present in the Global Pneumococcal Vaccine Market.

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Company Information

• Detailed analysis and profiling of additional market players (up to five).

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