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Forecast Period
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2026-2030
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Market Size (2024)
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USD 232.26 Million
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Market Size (2030)
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USD 311.47 Million
|
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CAGR (2025-2030)
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4.97%
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Fastest Growing Segment
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Aqueous Dry Eye Syndrome
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Largest Market
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Kanto
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Market Overview
Japan Dry Eye Medication Market was valued at USD 232.26
Million in 2024 and is expected to reach USD 311.47 Million
by 2030 with a CAGR of 4.97% during the forecast period. The Japan dry eye
medication market is driven by several key factors. Increasing prevalence of
dry eye disease, influenced by an aging population, lifestyle changes, and
prolonged screen time, is a primary driver. The rise in digital device usage
has exacerbated dry eye symptoms, creating a greater demand for effective treatments.
Advances in pharmaceutical research have introduced innovative therapies, such
as new lubricants, anti-inflammatory agents, and anti-allergic medications,
enhancing treatment options. Growing awareness and improved diagnostics have
led to earlier detection and better management of dry eye disease. The
increasing availability of advanced drug delivery systems, such as
sustained-release formulations, further supports market growth. Enhanced public
awareness campaigns and educational efforts by healthcare professionals also
contribute to the demand for dry eye medications, promoting proactive treatment
and management.
Key Market Drivers
Rising Prevalence of Dry Eye Disease
The escalating prevalence of dry eye disease in
Japan is a major driver of the dry eye medication market. Dry eye disease,
characterized by insufficient tear production or poor tear quality, is becoming
increasingly common in the country due to various lifestyle and environmental
factors. One of the primary contributors to the rise in dry eye cases is
Japan's aging population. As people age, tear production naturally declines,
making older adults more susceptible to dry eye symptoms. This demographic
shift significantly impacts the demand for dry eye treatments. According to
a study titled, “Prevalence and Risk Factors of Dry Eye Disease in Japan: Koumi
Study”, among a Japanese cohort, dry eye disease (DED) resulting in clinical
diagnosis or severe symptoms is notably prevalent. Contact lens (CL) use
emerged as a common risk factor for dry eye across both genders. Men with low
body mass index (BMI) and hypertension (HT), as well as women with a history of
myocardial infarction or angina and prolonged use of visual display terminals
(VDTs), were particularly affected. Out of 3,294 eligible residents, 2,791
(85%) completed the questionnaire. The prevalence of clinically diagnosed DED
or severe symptoms was higher in women (21.6%; 95% confidence interval [CI],
19.5–23.9) compared to men (12.5%; 95% CI, 10.7–14.5; P<0.001). In men, low BMI
(odds ratio [OR], 2.07; 95% CI, 0.98–4.39), CL use (OR, 3.84; 95% CI,
1.46–10.10), and hypertension (OR, 1.39; 95% CI, 0.94–2.06) were identified as
risk factors for DED. For women, risk factors included VDT use (OR, 2.33; 95%
CI, 1.12–4.85), CL use (OR, 3.61; 95% CI, 2.13–6.10), and myocardial infarction
or angina (OR, 2.64; 95% CI, 1.51–4.62), while high BMI acted as a preventive
factor (OR, 0.69; 95% CI, 0.48–1.01).
Modern lifestyle changes play a substantial role in
the growing incidence of dry eye disease. The extensive use of digital devices,
such as smartphones, computers, and tablets, has become ubiquitous in Japan.
Prolonged screen time is known to reduce blink rates, which in turn decreases
the spread of tears across the ocular surface and leads to increased dryness.
This trend is further compounded by the high pace of work and daily life in
urban areas, where individuals often spend long hours in front of screens,
exacerbating their dry eye symptoms. Environmental factors also contribute to
the increasing prevalence of dry eye disease. The frequent use of air
conditioning and heating systems in both personal and professional environments
creates a dry indoor atmosphere. These systems can reduce the humidity levels
in the air, which exacerbates ocular surface dryness and contributes to the
discomfort associated with dry eye disease. The combination of these
environmental factors with prolonged exposure to digital screens creates a
challenging situation for individuals suffering from dry eye, increasing their
need for effective therapeutic solutions.
The growing awareness of dry eye disease and its
impact on quality of life is driving market demand for effective treatments. As
more individuals recognize the symptoms and seek relief from the discomfort
associated with dry eye, the market for dry eye medications is expanding. This
increased awareness is partly fueled by public health campaigns and
advancements in diagnostic technologies that allow for earlier and more
accurate detection of dry eye disease. Enhanced diagnostics, such as improved
tear break-up time tests and advanced ocular surface assessments, enable
healthcare providers to identify and manage dry eye more effectively, further
stimulating demand for therapeutic options. Pharmaceutical companies are
responding to this rising demand by developing and offering a wider range of
dry eye treatments tailored to the specific needs of Japanese patients.
Innovations in medication formulations, drug delivery systems, and therapeutic
approaches are being introduced to address various aspects of dry eye disease.
For instance, the development of advanced artificial tears that provide
longer-lasting relief and new anti-inflammatory drugs that target underlying
causes of dry eye are contributing to market growth. The increasing
availability of prescription treatments, such as anti-VEGF therapies and
immunomodulatory agents, offers patients more comprehensive options for
managing their condition.
Advancements in Pharmaceutical Research
Advancements in pharmaceutical research have played
a pivotal role in shaping the growth of the dry eye medication market in Japan.
Recent innovations in therapeutic approaches have significantly enhanced the
management of dry eye disease, addressing both its symptoms and underlying
causes with greater precision and effectiveness.
One of the major advancements in the field is the
development of new classes of medications that target specific aspects of dry
eye disease. Anti-inflammatory agents, for example, have been introduced to
address the chronic inflammation of the ocular surface, a key factor in the
pathophysiology of dry eye. These medications work by reducing inflammation,
which not only alleviates symptoms but also helps to prevent further damage to
the ocular surface. The efficacy of these agents represents a significant
improvement over traditional treatments, making them a valuable addition to the
therapeutic arsenal for managing dry eye disease.
Advancements in drug delivery systems have markedly
improved the efficacy and convenience of dry eye treatments. Sustained-release
formulations, which allow for the gradual release of medication over an
extended period, provide longer-lasting relief from dry eye symptoms. This
approach reduces the frequency of application and enhances patient compliance.
Similarly, liposomal eye drops have been developed to improve the stability and
effectiveness of treatment. These drops encapsulate the therapeutic agents in
lipid layers, enhancing their ability to penetrate the ocular surface and
deliver targeted relief. Such innovations in drug delivery not only improve the
therapeutic outcomes but also offer a more user-friendly experience for
patients. The development of new and improved formulations has also contributed
to better patient compliance and overall outcomes. Advanced formulations are
designed to address specific symptoms of dry eye, such as discomfort and
dryness, more effectively than previous treatments. For example, newer
artificial tear products may include additional components that mimic natural
tear film properties, providing more comprehensive relief. These innovations
are aimed at meeting the diverse needs of patients and improving their quality
of life.
Availability of Advanced Drug Delivery Systems
The development of advanced drug delivery systems
has profoundly impacted the dry eye medication market in Japan, driving
significant changes in how treatments are administered and experienced by
patients. Innovations in drug delivery technologies have ushered in a new era of
therapeutic options that enhance both the effectiveness and convenience of
managing dry eye disease. One of the key advancements is the introduction of
sustained-release formulations. These systems are designed to release
medication gradually over an extended period, which helps maintain therapeutic
levels in the ocular surface with fewer applications. This continuous release
reduces the need for frequent dosing, which not only improves patient adherence
but also ensures more consistent symptom relief. By minimizing the frequency of
application, sustained-release formulations address one of the common barriers
to treatment compliance, making them an attractive option for both patients and
healthcare providers.
Hydrogels represent another significant innovation
in drug delivery for dry eye treatments. These are water-absorbing polymers
that can hold and slowly release therapeutic agents over time. Hydrogels offer
several advantages, including enhanced comfort and improved retention on the
ocular surface. Their ability to provide a moist environment helps in
stabilizing the tear film, which is crucial for effective dry eye management.
The use of hydrogels can significantly improve the patient experience by
reducing the discomfort often associated with traditional eye drops and
providing longer-lasting relief. Liposomal eye drops have also emerged as a
major breakthrough in the field. These drops incorporate medications into tiny
lipid-based vesicles, which protect the active ingredients and facilitate their
delivery to the ocular surface. The liposomes help in enhancing the stability
and bioavailability of the therapeutic agents, making them more effective at
treating dry eye symptoms. Liposomal formulations can mimic the natural tear
film more closely, which improves their ability to lubricate and protect the
eye. This innovation not only enhances the efficacy of the treatment but also
contributes to a better overall patient experience.
Support from Healthcare Policies and Regulations
Support from healthcare policies and regulations
plays a vital role in driving the Japan dry eye medication market. Government
initiatives and healthcare policies aimed at improving the management and
treatment of dry eye disease contribute to the market's growth. Reimbursement policies,
coverage of dry eye medications under national health insurance, and support
for research and development in the field enhance access to treatment and
foster innovation. Regulatory agencies in Japan are actively involved in
approving new therapies and ensuring their safety and efficacy. The supportive
regulatory environment and healthcare policies facilitate the introduction and
adoption of new dry eye medications, driving market expansion. The alignment of
healthcare policies with the needs of patients and advancements in therapeutic
options supports the growth of the dry eye medication market in Japan.
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Key Market Challenges
Limited Awareness and Underdiagnosis
Limited awareness and underdiagnosis of dry eye disease
present another significant challenge for the Japan dry eye medication market.
Despite increasing public awareness campaigns, many patients with dry eye
symptoms may not recognize the condition or may attribute their symptoms to
other causes. This can lead to delayed diagnosis and treatment, affecting the
overall effectiveness of therapeutic interventions. Healthcare providers may
not always have the most up-to-date knowledge of the latest diagnostic and
treatment options, leading to underdiagnosis or suboptimal management of dry
eye disease. The lack of standardized diagnostic protocols and insufficient
training for healthcare professionals can further exacerbate the issue.
Addressing these gaps in awareness and diagnosis is crucial for improving patient
outcomes and driving market growth.
Competition from Over-the-Counter Products
The presence of a wide range of over-the-counter
(OTC) products for dry eye relief presents a challenge to the Japan dry eye
medication market. Many patients may choose OTC remedies, such as artificial
tears and lubricating eye drops, over prescription medications due to their
lower cost and ease of availability. While these OTC products can provide
temporary relief, they may not address the underlying causes of dry eye disease
or offer the same level of efficacy as prescription treatments. The competitive
landscape created by OTC products can impact the market share of prescription
medications and create barriers to market growth. To counteract this challenge,
pharmaceutical companies must differentiate their products through superior
efficacy, advanced formulations, and evidence-based benefits to encourage
patients and healthcare providers to opt for prescription therapies.
Key Market Trends
Enhanced Diagnostic Technologies
The advancement of diagnostic technologies has
significantly impacted the Japan dry eye medication market, ushering in a new
era of precision in diagnosing and managing dry eye disease. Enhanced
diagnostic tools have revolutionized the way healthcare providers detect,
evaluate, and treat this prevalent condition, leading to a more effective and
personalized approach to patient care.
Optical Coherence Tomography (OCT) represents a
major leap forward in dry eye diagnostics. OCT is a non-invasive imaging technique
that provides high-resolution cross-sectional images of the ocular structures,
particularly the retina and the cornea. This advanced imaging technology allows
clinicians to assess the thickness and integrity of the corneal epithelium and
other key layers, which are crucial for understanding the severity of dry eye
disease. By visualizing changes in the ocular surface at a microscopic level,
OCT enables early detection of pathological alterations associated with dry
eye. This capability is instrumental in diagnosing the condition before it
progresses to more severe stages, thus allowing for earlier and potentially
more effective intervention. Tear Break-Up Time (TBUT) tests are another
essential advancement in dry eye diagnostics. TBUT measures the stability of
the tear film by evaluating how quickly tears evaporate from the surface of the
eye. This test is straightforward yet highly effective in determining the
presence of dry eye symptoms and assessing the functional integrity of the tear
film. Advances in TBUT testing have led to more precise and reliable
measurements, helping clinicians diagnose dry eye more accurately. The ability
to obtain detailed information about tear film stability enhances the
diagnostic process and supports the development of tailored treatment plans
that address the specific needs of each patient.
Increasing Screen Time and Digital Device Usage
The widespread use of digital devices and the
accompanying increase in screen time have significantly impacted the prevalence
and management of dry eye disease in Japan, contributing to a burgeoning market
for dry eye medications. As technology continues to evolve, modern lifestyles
have increasingly revolved around extensive use of computers, smartphones, and
tablets. This constant engagement with digital screens has introduced a host of
new challenges for eye health, prominently affecting the ocular surface and
exacerbating dry eye symptoms. The phenomenon of "digital eye strain"
or "computer vision syndrome" has become a major concern as
individuals spend extended periods interacting with screens. The primary issue
stems from the reduction in blink frequency that occurs when people focus on
digital devices. Blinking is a critical physiological process that helps to spread
tears evenly across the ocular surface, maintaining moisture and removing
debris. However, when people are deeply engrossed in screen activities, their
blink rate significantly decreases. This decreased frequency of blinking leads
to an inadequate distribution of tears, which in turn contributes to an
increase in ocular surface dryness and discomfort. According to a 2021
survey in Japan revealed that men in their twenties averaged 206 minutes per
day on their smartphones. In contrast, men over the age of 40 spent more time
watching television than using their smartphones, a trend not observed among
younger generations.
Prolonged screen use often results in the exposure
of the eyes to harsh lighting conditions, such as bright screens and
high-contrast displays. These factors can exacerbate the drying effect on the
eyes and further aggravate symptoms of dry eye disease. The combination of
reduced blinking and environmental factors creates a perfect storm for the
development and worsening of dry eye symptoms, including irritation, redness,
and a gritty sensation in the eyes. The rising incidence of dry eye disease,
driven by increased digital device usage, has spurred a significant demand for
effective treatments. Patients experiencing digital eye strain seek relief from
the discomfort associated with prolonged screen exposure, leading to a
heightened interest in dry eye medications. As awareness of the impact of
digital screen time on eye health grows, both healthcare professionals and
patients are increasingly recognizing the need for effective therapeutic
solutions.
Segmental Insights
Disease Type Insights
Based on the Disease Type, Aqueous
Dry Eye Syndrome was currently the dominated form of dry eye disease. This
condition is characterized by a deficiency in the production of tears, which
leads to insufficient moisture on the ocular surface. Aqueous dry eye syndrome
occurs when the lacrimal glands, responsible for producing the aqueous
component of tears, are not functioning properly. This results in symptoms such
as dryness, irritation, and a feeling of grittiness in the eyes. Several
factors contribute to the predominance of aqueous dry eye syndrome in Japan.
One of the primary drivers is the aging population, as the incidence of aqueous
dry eye syndrome increases with age. The natural aging process leads to a
gradual decline in tear production, making older adults more susceptible to
this type of dry eye disease. With Japan having one of the world’s most rapidly
aging populations, the prevalence of aqueous dry eye syndrome has consequently
risen. Another significant factor is the impact of environmental and lifestyle
changes. The urbanized and technologically driven lifestyle in Japan,
characterized by long hours spent in front of digital screens, contributes to
the exacerbation of aqueous dry eye symptoms. Prolonged screen use reduces
blinking rates, which in turn decreases tear distribution and exacerbates
dryness. Exposure to air conditioning and heating systems in both personal and
professional environments further aggravates aqueous dry eye syndrome by drying
out the ocular surface.
The treatment landscape for
aqueous dry eye syndrome is heavily influenced by the development and
availability of various therapeutic options. Medications such as artificial
tears, anti-inflammatory agents, and other tear substitutes are commonly used
to manage the symptoms associated with this condition. Pharmaceutical companies
have developed a range of products specifically targeting aqueous dry eye
syndrome, reflecting its dominant position in the market. Advances in drug
formulations, including sustained-release and preservative-free options, have
enhanced the effectiveness and patient acceptance of these treatments. In
addition, the prevalence of aqueous dry eye syndrome is supported by the high
rates of autoimmune conditions such as Sjögren’s syndrome in Japan. Sjögren’s
syndrome is a chronic autoimmune disease that primarily affects the lacrimal
and salivary glands, leading to significant reductions in tear production and
salivation. As autoimmune disorders are more prevalent among the aging
population, their impact on tear production further contributes to the
dominance of aqueous dry eye syndrome.
Drug Type Insights
Based on Drug Type, lubricant
eye drops was currently the dominated therapy. Lubricant eye drops, often
referred to as artificial tears, are extensively used to manage symptoms of dry
eye disease by providing temporary relief through lubrication of the ocular
surface. The prevalence of dry eye disease in Japan, exacerbated by lifestyle
factors and an aging population, has driven the high demand for lubricant eye
drops. These drops are designed to mimic natural tears and alleviate symptoms
such as dryness, irritation, and a gritty sensation in the eyes. Their
widespread use is attributed to their effectiveness, accessibility, and the
ease with which they can be administered by patients. Lubricant eye drops come
in various formulations, including those with different viscosities and
preservative-free options. This variety allows for tailored treatments based on
individual patient needs and preferences. The choice between different types of
lubricant eye drops often depends on factors such as the severity of symptoms,
frequency of application, and potential sensitivity to preservatives.
One of the key reasons for
the dominance of lubricant eye drops in the market is their immediate efficacy
in alleviating dry eye symptoms. They provide quick relief by creating a film
over the ocular surface, which helps to stabilize the tear film and reduce
evaporation. This immediate effect makes them a popular choice among patients
seeking quick and effective relief from dry eye discomfort. Lubricant eye drops
are widely available both over-the-counter and through prescription,
contributing to their dominance in the market. Their availability in
pharmacies, online stores, and healthcare facilities ensures that patients have
easy access to these medications, further driving their use. The convenience and
affordability of lubricant eye drops make them a first-line treatment for many
individuals experiencing dry eye symptoms. The continued advancements in the
formulation of lubricant eye drops also play a significant role in their market
dominance. Innovations such as sustained-release formulations and improved
delivery systems enhance the effectiveness and patient compliance. For
instance, sustained-release formulations reduce the frequency of application
required, which can be particularly beneficial for patients with moderate to
severe dry eye disease.
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Regional Insights
In the Japan dry eye medication market, the Kanto
region stands out as the dominant area. The Kanto region, which includes major
metropolitan areas such as Tokyo and Yokohama, is a central hub of economic
activity, healthcare infrastructure, and population density in Japan. This
concentration of population and resources plays a pivotal role in driving the
demand for dry eye medications. The Kanto region's prominence in the dry eye
medication market can be attributed to several factors. The high population
density in urban centers like Tokyo contributes to a significant number of
individuals affected by dry eye disease. The fast-paced lifestyle and extended screen
time associated with city living exacerbate the prevalence of dry eye symptoms.
As a result, there is a higher demand for effective treatments and therapeutic
options in these densely populated areas.
The Kanto region is home to some of Japan's leading
medical institutions, research facilities, and pharmaceutical companies. This
concentration of healthcare infrastructure fosters innovation and provides
access to advanced diagnostic and therapeutic technologies. The presence of
major research institutions and clinical centers in the Kanto region
facilitates the development and distribution of cutting-edge dry eye
treatments, further boosting the market's growth. The region's economic
strength also contributes to its dominance in the dry eye medication market.
With a robust economy and higher disposable incomes, residents in the Kanto
region have greater access to healthcare services and are more likely to seek
out and afford specialized treatments for dry eye disease. The availability of
premium and advanced dry eye medications is more prevalent in this economically
prosperous area, leading to increased market activity.
The Kanto region benefits from its strategic
location as a transportation and distribution hub. This accessibility ensures
efficient distribution of dry eye medications across the region, making it
easier for patients to obtain necessary treatments. The region's well-developed
infrastructure supports a steady supply of medications, contributing to its
dominant position in the market. The high level of awareness and education
about dry eye disease in the Kanto region also plays a significant role. Public
awareness campaigns and educational initiatives about the importance of
managing dry eye symptoms and seeking timely treatment are more prominent in
this area. This heightened awareness translates into a greater demand for dry
eye medications and proactive management of the condition.
Recent Developments
- In April 2024, Santen
Pharmaceutical Co., Ltd., a Japanese company specializing in ophthalmic
products, announced plans to address the increasing demand for eye care
products in China, particularly due to the country's aging population. The
Osaka-based firm recently completed the construction of its new facility,
Santen Vision Park, in Suzhou, Jiangsu Province. China, after Japan, represents
one of Santen's largest international markets in terms of both business and
operational scale. The newly built, highly automated factory in Suzhou
Industrial Park will support the company's existing facility in the city. This
new plant is expected to meet the growing demand for prescription ophthalmic
solutions in China and strengthen Santen’s production and supply capabilities
in the region.
- In February 2024, Nicox SA,
announced a new agreement with Kowa Company, Ltd., a pioneering Japanese
pharmaceutical firm with a strong focus on innovative research, development,
and marketing. This agreement grants Kowa exclusive rights in Japan to develop
and commercialize NCX 470, Nicox’s nitric oxide (NO)-donating bimatoprost eye
drop. NCX 470 is designed to reduce intraocular pressure (IOP) in patients with
glaucoma or ocular hypertension.
- In June 2023, Senju
Pharmaceutical Co., Ltd., a research-driven Japanese pharmaceutical firm
specializing in ophthalmology, and Novaliq GmbH, a biopharmaceutical company
renowned for its innovative ocular therapeutics utilizing the proprietary
EyeSol water-free technology, announced the completion of a licensing
agreement. This agreement grants Senju Pharmaceutical the rights to develop,
manufacture, and market NOV03 (perfluorohexyloctane ophthalmic solution) in
Japan. NOV03 is distinguished as the first and only prescription treatment
specifically designed to address tear evaporation in dry eye disease.
Key Market Players
- AbbVie GK
- Novartis Pharma K.K.
- Santen Pharmaceutical Co., Ltd.
- Janssen Pharmaceuticals K.K.
- Senju Pharmaceutical Co., Ltd.
- Taisho Pharmaceutical Co., Ltd
- Otsuka Pharmaceutical Co., Ltd.
- Sun Pharma Japan Limited
- Asahi Kasei Pharma Corporation
- Kyowa Pharmaceutical Industry Co., Ltd.
|
By Disease Type
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By Drug Type
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By Product
|
By Distribution Channel
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By Region
|
- Evaporative Dry Eye Syndrome
- Aqueous Dry Eye Syndrome
|
- Anti-inflammatory Drugs
- Lubricant Eye Drops
- Autologous Serum Eye Drops
|
- Liquid Drops
- Gel
- Liquid Wipes
- Eye Ointment
- Others
|
- Hospital Pharmacies
- Retail Pharmacies
- Online Pharmacies
|
- Hokkaido
- Tohoku
- Kanto
- Chubu
- Kansai
- Chugoku
- Shikoku
- Kyushu
|
Report Scope:
In this report, the Japan Dry Eye Medication Market
has been segmented into the following categories, in addition to the industry
trends which have also been detailed below:
- Japan Dry Eye Medication
Market, By
Disease Type:
o Evaporative Dry Eye Syndrome
o Aqueous Dry Eye Syndrome
- Japan Dry Eye Medication
Market, By
Drug Type:
o Anti-inflammatory Drugs
o Lubricant Eye Drops
o Autologous Serum Eye Drops
- Japan Dry Eye Medication
Market, By
Product:
o Liquid Drops
o Gel
o Liquid Wipes
o Eye Ointment
o Others
- Japan Dry Eye Medication
Market, By
Distribution Channel:
o Hospital Pharmacies
o Retail Pharmacies
o Online Pharmacies
- Japan Dry Eye Medication
Market, By
Region:
o Hokkaido
o Tohoku
o Kanto
o Chubu
o Kansai
o Chugoku
o Shikoku
o Kyushu
Competitive Landscape
Company Profiles: Detailed analysis of the major companies
present in the Japan Dry Eye Medication Market.
Available Customizations:
Japan Dry Eye Medication Market report with
the given market data, TechSci Research offers customizations according to a
company's specific needs. The following customization options are available for
the report:
Company Information
- Detailed analysis and
profiling of additional market players (up to five).
Japan Dry Eye Medication Market is an upcoming
report to be released soon. If you wish an early delivery of this report or
want to confirm the date of release, please contact us at [email protected]