|
Forecast Period
|
2026-2030
|
|
Market Size (2024)
|
USD 1.84 Billion
|
|
Market Size (2030)
|
USD 2.73 Billion
|
|
CAGR (2025-2030)
|
9.76%
|
|
Fastest Growing Segment
|
Antibody DNA synthesis
|
|
Largest Market
|
North America
|
Market Overview
Global Gene Synthesis
Market was valued at USD 1.84 Billion in 2024 and is expected to reach USD 2.73
Billion by 2030 with a CAGR of 9.76% during the forecast period. The Gene Synthesis market is a burgeoning
sector within the biotechnology industry, characterized by the custom
production of artificial DNA sequences. It plays a pivotal role in various
fields such as genetic engineering, pharmaceuticals, and synthetic biology. The
market's growth is primarily driven by advancements in DNA synthesis
technologies, reduced costs, and increasing demand for tailored genetic
constructs for research and therapeutic purposes.In January
2022, the U.S. Food and Drug Administration (FDA) granted a second approval to
Moderna’s mRNA-based COVID-19 vaccine, Spikevax. This highlighted the critical
role of gene synthesis during the pandemic, with the market anticipated to
experience further growth.
With applications ranging
from vaccine development to gene therapy, the Gene Synthesis market is poised
for continued expansion as it empowers scientists and researchers to design and
construct genes with precision, fostering innovation across multiple domains.
Key Market Drivers
Rising
investment in synthetic biology market
The
rising investment in the synthetic biology market has emerged as a significant
driver for the Gene Synthesis market. Synthetic biology, a multidisciplinary
field that combines biology with engineering principles, is experiencing a
surge in funding and interest from various sectors, including biotechnology,
pharmaceuticals, energy, and agriculture. This investment is fundamentally
reshaping the landscape of genetic research and applications, with gene
synthesis playing a pivotal role. One key aspect of synthetic biology is the
design and construction of novel biological parts, devices, and systems. Gene
synthesis is the enabling technology that allows scientists and engineers to
create custom DNA sequences with precision. As investment in synthetic biology
grows, there is a heightened demand for synthesized genes to build and optimize
synthetic biological systems. Researchers are increasingly relying on gene
synthesis services to design and produce the genetic components required for
their projects, from engineered microbes for biomanufacturing to gene circuits
for medical applications.
Moreover,
the expansion of synthetic biology into diverse industries such as
biomanufacturing, biofuels, agriculture, and healthcare is propelling the Gene
Synthesis market forward. Investment in these sectors is driving innovation and
driving the need for synthetic genes tailored to specific applications. This
symbiotic relationship between synthetic biology and gene synthesis is creating
a feedback loop, with each field reinforcing the other's growth. Furthermore,
the infusion of capital into synthetic biology startups and research
initiatives is fostering technological advancements in gene synthesis.
Companies are investing in research and development to improve the efficiency,
cost-effectiveness, and automation of gene synthesis processes. These innovations
are making gene synthesis more accessible and affordable, attracting a broader
range of researchers and industries. In conclusion, the rising investment in
the synthetic biology market serves as a powerful catalyst for the Gene
Synthesis market. It fuels demand for custom DNA sequences, accelerates
innovation in genetic engineering, and supports the development of novel
applications across various sectors. As synthetic biology continues to
flourish, the Gene Synthesis market is likely to see sustained growth and
transformation, unlocking new possibilities in biotechnology and beyond.
Advent
of enzymatic DNA synthesis process
The
advent of enzymatic DNA synthesis processes has emerged as a significant driver
for the Gene Synthesis market, transforming the landscape of genetic research
and biotechnology applications. Enzymatic DNA synthesis represents a
revolutionary leap forward in the field of gene synthesis, offering several key
advantages that are reshaping the industry. Firstly, enzymatic DNA synthesis
methods, such as DNA polymerase-based techniques, provide higher fidelity and
accuracy compared to traditional chemical synthesis approaches. This results in
fewer errors and mutations in synthesized genes, making them more reliable for
scientific research, drug development, and therapeutic applications.
Researchers and biotech companies increasingly turn to enzymatic synthesis for
their need for precise and error-free DNA constructs. Secondly, enzymatic DNA
synthesis is more sustainable and environmentally friendly. It reduces the use
of hazardous chemicals and solvents typically associated with chemical DNA
synthesis, aligning with the growing emphasis on eco-friendly practices in the
biotechnology sector. This sustainability aspect not only appeals to
environmentally conscious organizations but also reflects positively on the
reputation of gene synthesis providers.
Furthermore,
enzymatic DNA synthesis processes offer greater flexibility and scalability.
Researchers can easily modify and optimize DNA sequences, enabling rapid
iterations for experimental design and adaptation to changing research needs.
The scalability of enzymatic synthesis allows for the efficient production of
both small-scale research constructs and large-scale industrial applications,
such as biofuel production or gene therapy vectors. Enzymatic synthesis also
contributes to cost-effectiveness. While the initial development and
optimization of enzymatic processes may require investment, the long-term
benefits include reduced reagent costs, decreased labor requirements, and
higher yields of error-free DNA sequences. This affordability has expanded the
accessibility of gene synthesis services to a broader range of researchers and
industries. The advent of enzymatic DNA synthesis processes is a driving force
behind the Gene Synthesis market's growth. It has elevated the precision,
sustainability, flexibility, and cost-effectiveness of gene synthesis, making
it an indispensable tool in genetic research, biotechnology, and the
development of innovative solutions across multiple sectors. As enzymatic DNA
synthesis technologies continue to evolve and gain wider adoption, they are
poised to shape the future of gene synthesis.
Technological
advancements in the DNA synthesis platforms
Technological
advancements in DNA synthesis platforms are serving as powerful drivers for the
Gene Synthesis market, catalyzing innovation and expanding the applications of
synthesized genes across various fields. These advancements are fundamentally
transforming the landscape of genetic research and biotechnology. One of the
key ways in which technological advancements are driving the Gene Synthesis
market is through increased efficiency and speed. Modern DNA synthesis
platforms leverage innovative techniques such as microarray-based synthesis and
inkjet printing, enabling the parallel synthesis of multiple DNA sequences in a
high-throughput manner. This dramatically reduces the time required to generate
synthetic genes, facilitating quicker research outcomes and product development
in areas such as drug discovery, genetic engineering, and vaccine development. In April
2022, DNA Script introduced an early access program for SYNTAX system customers,
providing organizations with early access to the latest advancements in its enzymatic
DNA synthesis technology.
Moreover,
advancements in DNA synthesis have led to increased accuracy and precision.
Error rates in synthesized genes have been significantly reduced, ensuring that
the genetic constructs produced are reliable and functional. This heightened
fidelity is critical for applications like gene therapy and the creation of
genetically modified organisms, where precise genetic modifications are
essential for success.
Technological
progress has also contributed to cost reduction in gene synthesis. The
optimization of synthesis protocols and the development of more efficient
synthesis chemistries have lowered the overall cost of producing synthetic DNA
sequences. As a result, gene synthesis services have become more accessible to
a wider range of researchers and organizations, fueling market growth. Furthermore,
technological advancements have led to the development of user-friendly
software tools for gene design and ordering. Researchers can now easily design
and order custom DNA sequences through online platforms, streamlining the
entire gene synthesis process. This accessibility and convenience have
democratized genetic research and encouraged a broader adoption of gene
synthesis services. Technological advancements in DNA synthesis platforms are
revolutionizing the Gene Synthesis market by enhancing efficiency, accuracy,
affordability, and accessibility. As these platforms continue to evolve, they
are enabling breakthroughs in genetics, genomics, and biotechnology, ultimately
driving innovation and expanding the frontiers of scientific discovery and
commercial applications. The future of gene synthesis holds tremendous
potential as technology continues to advance, opening up new possibilities for
customized genetic solutions across diverse industries.
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Key Market
Challenges
Lack
of skilled professionals
The
Gene Synthesis market faces a significant challenge in the form of a shortage
of skilled professionals, which poses hurdles to its growth and advancement.
This scarcity of expertise impacts various facets of the gene synthesis
industry and has multifaceted consequences. Firstly, gene synthesis involves
intricate molecular biology techniques and a deep understanding of DNA
manipulation. Without a sufficient number of skilled professionals, the
industry may experience delays in project timelines, reduced efficiency, and increased
risk of errors in synthesized DNA sequences. This shortage of expertise can
hinder research and development efforts in areas such as drug discovery,
genetic engineering, and synthetic biology, where precision and accuracy are
paramount.
Moreover,
the lack of skilled professionals limits the capacity for innovation and
technological advancement within the Gene Synthesis market. Talented scientists
and engineers are essential for driving the development of new synthesis
methods, automation technologies, and software tools that enhance the
efficiency and capabilities of gene synthesis platforms. Without a skilled
workforce, the industry may struggle to keep pace with emerging trends and
evolving customer needs. Additionally, as the demand for gene synthesis
services grows across diverse industries, there is an increased need for
professionals who can not only synthesize genes but also design and optimize
genetic constructs for specific applications. The shortage of such specialists
can constrain the market's ability to provide tailored solutions to researchers
and organizations with unique genetic engineering requirements. Furthermore,
the Gene Synthesis market relies on a workforce that understands and adheres to
strict ethical and biosecurity standards, especially as concerns about misuse
of synthesized DNA arise. Skilled professionals are essential for implementing
and enforcing these standards to ensure responsible and secure use of gene
synthesis services. To
address these challenges, efforts are needed to invest in education and
training programs that cultivate a new generation of skilled gene synthesis
professionals. Collaboration between academic institutions, industry, and
regulatory bodies can help bridge the skills gap and foster a workforce capable
of driving innovation and responsible use of gene synthesis technologies. In
doing so, the Gene Synthesis market can overcome the obstacle posed by the
shortage of skilled professionals and continue to thrive in the era of genetic
advancement.
Misuse
of gene synthesis
The
misuse of gene synthesis technology presents a significant challenge for the
Gene Synthesis market, raising ethical, biosecurity, and regulatory concerns
that can impact the industry's growth and reputation. One of the foremost
challenges is the potential for synthesized genes to be used in harmful or
malicious ways. As gene synthesis becomes more accessible, there is a risk that
individuals or groups with nefarious intentions could request the synthesis of genes
for dangerous pathogens or toxins. This misuse poses a serious biosecurity
threat, as it could lead to the creation of bioweapons or the accidental
release of harmful agents into the environment. To mitigate this risk, gene
synthesis providers must implement robust screening and verification processes
to ensure that requested sequences do not pose biosecurity risks. However,
striking the right balance between facilitating legitimate research and preventing
misuse is a complex task. Additionally, ethical concerns arise from the
potential misuse of gene synthesis in areas such as human cloning or the
creation of genetically modified organisms with unintended consequences. The
ethical implications of gene synthesis extend to issues like genetic
discrimination, privacy, and consent, further complicating the landscape for
the industry.
Furthermore,
regulatory bodies are grappling with how to effectively oversee and govern gene
synthesis activities. The dynamic nature of gene synthesis, with rapidly
evolving technologies and international accessibility, makes it challenging to
establish and enforce consistent regulations. Striking the right balance
between facilitating scientific progress and preventing misuse is a delicate
challenge for regulators. The perception of misuse and the associated ethical
and biosecurity concerns can also affect the public's perception of the Gene
Synthesis market. Negative perceptions may lead to increased scrutiny, stricter
regulations, and public distrust, potentially hindering the industry's growth
and acceptance. Addressing
these challenges requires collaboration between gene synthesis providers,
researchers, regulatory bodies, and biosecurity experts to establish clear
guidelines, enhance screening processes, and promote responsible practices.
Ensuring that gene synthesis is used for legitimate, beneficial purposes while
safeguarding against misuse is vital to the long-term sustainability and
reputation of the Gene Synthesis market.
Key Market Trends
Growth
in Personalized Medicine
The
Gene Synthesis market is experiencing a significant trend driven by the growth
of personalized medicine. Personalized medicine involves tailoring medical
treatments and interventions to an individual's genetic makeup. This approach
requires the development of custom-designed genetic constructs, which is where
gene synthesis plays a pivotal role. In January
2024, Twist Bioscience introduced Twist Express Genes, a new service providing high-quality
synthetic DNA, including larger DNA preparations of up to 1 milligram, with
delivery in as little as five business days.
As
personalized medicine gains prominence, the demand for synthesized genes for
research, diagnostics, and therapeutic applications surges. Gene synthesis
allows the creation of precise genetic tools, such as patient-specific gene
therapies, gene editing components, and diagnostic probes. These custom genetic
constructs enable healthcare providers to develop treatments that are uniquely
suited to an individual's genetic profile, maximizing effectiveness and
minimizing adverse effects. The Gene Synthesis market is poised to benefit from
this trend, as it becomes an indispensable part of the personalized medicine
ecosystem. The ability to rapidly and accurately produce tailored genetic
material aligns with the evolving healthcare landscape, offering hope for more
effective and personalized medical solutions.
Expanded
Use in Vaccines
The
Gene Synthesis market is experiencing a notable trend driven by the expanded
use of synthesized genes in vaccine development. This trend is particularly
significant in the context of emerging infectious diseases and the need for
rapid vaccine development. Gene synthesis enables the quick and precise
production of viral genetic material, making it essential for developing
synthetic versions of viruses for vaccine research.The
biotechnology company United Therapeutics has partnered with synthetic biology
firm Revivicor to develop genetically modified pig lungs. Their research aims
to implement precise genetic modifications to improve immune compatibility and
extend the lifespan of transplanted organs. In 2023, they reported promising
preclinical results, marking significant progress toward human clinical trials.
During global health crises
like the COVID-19 pandemic, gene synthesis played a critical role in expediting
the development of vaccines by providing researchers with access to the genetic
information needed to design vaccine candidates. Furthermore, the flexibility
of gene synthesis allows for the engineering of vaccines with enhanced safety
and efficacy. Researchers can customize vaccine constructs to optimize immune
responses, ensuring better protection against infectious agents. As infectious
diseases continue to pose global health threats, the Gene Synthesis market is
expected to see continued growth in demand for its services to support vaccine
development efforts. This trend underscores the importance of gene synthesis in
the healthcare and biotechnology sectors and its contribution to public health.
Segmental Insights
Method
Insights
Based on method, Solid-phase
synthesis has dominated the gene synthesis market due to its efficiency,
accuracy, and scalability. This method revolutionized gene synthesis by
addressing several key challenges faced by earlier liquid-phase synthesis
techniques. Firstly, solid-phase synthesis allows for the step-by-step assembly
of DNA sequences on a solid support matrix. This significantly reduces the risk
of errors and ensures high-fidelity synthesis as each nucleotide is added
sequentially. Accuracy is paramount in gene synthesis to avoid mutations and
ensure the functionality of the synthesized genes, making solid-phase synthesis
highly advantageous. Secondly, solid-phase synthesis offers excellent
scalability. Multiple reactions can occur simultaneously on a solid support,
allowing for the parallel synthesis of numerous DNA fragments. This
high-throughput capability accelerates the gene synthesis process, making it
more time-efficient and cost-effective, a crucial factor in the competitive
gene synthesis market. Additionally, solid-phase synthesis is amenable to
automation, enabling robotic platforms to carry out complex synthesis reactions
with precision. This automation further enhances speed, accuracy, and
reproducibility, making solid-phase synthesis the preferred choice for
high-throughput gene synthesis services.
Furthermore,
solid-phase synthesis reduces the need for purification steps between each
synthesis cycle, simplifying the overall process and decreasing the chances of
contamination. In summary, solid-phase synthesis has dominated the gene
synthesis market because it offers a combination of accuracy, scalability, and
automation capabilities that are essential for efficient and cost-effective
gene synthesis services. Its ability to produce high-quality, error-free
synthetic genes quickly has established it as the method of choice in the gene
synthesis industry.
End
Use Insights
Based on end- use, Academic
and government research institutes have played a dominant role in the gene
synthesis market due to several key factors. Firstly, these institutions are
often at the forefront of scientific research and innovation. They require gene
synthesis services for a wide range of research projects spanning genomics,
molecular biology, biotechnology, and more. The academic environment fosters
curiosity and exploration, driving the demand for custom-designed DNA sequences
to support cutting-edge studies. As a result, academic and government research
institutes have become significant consumers of gene synthesis services. Secondly,
academic institutions and government-funded research centers frequently have
access to grant funding, which they can allocate toward gene synthesis
projects. This financial support enables them to undertake ambitious research
endeavors that often necessitate the synthesis of specific DNA sequences. This
funding advantage allows them to be active players in the gene synthesis
market. Furthermore, these institutions often serve as hubs of collaboration
and knowledge-sharing. They regularly engage with external partners, including
gene synthesis providers, to access specialized expertise and resources. This
collaboration fosters innovation and the exchange of ideas, driving the demand
for gene synthesis services.
Additionally,
academic and government research institutes often prioritize open-access and
knowledge dissemination. They frequently publish their research findings,
showcasing the value and importance of gene synthesis in various scientific
fields. This emphasis on sharing knowledge helps promote the gene synthesis
market by highlighting its significance in advancing scientific understanding. In
conclusion, academic and government research institutes dominate the gene
synthesis market because of their substantial research needs, access to
funding, collaborative nature, and commitment to advancing knowledge. Their
role as leaders in scientific exploration ensures that gene synthesis remains a
vital tool in pushing the boundaries of scientific discovery.
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Regional Insights
North
America emerged as a dominant force in the gene synthesis market due to a combination
of factors that have fostered its growth and leadership in the industry. Firstly,
North America boasts a robust and highly developed biotechnology and
pharmaceutical sector. The region is home to numerous biotech companies,
research institutions, and academic centers that rely heavily on gene synthesis
services for a wide range of applications, from drug development to genetic
engineering. This concentration of biotechnology expertise drives substantial
demand for gene synthesis. Secondly, the region has a well-established
ecosystem that supports innovation and entrepreneurship. The availability of
venture capital, angel investors, and supportive government policies has
nurtured a thriving biotech startup scene. Many of these startups focus on cutting-edge
research and development projects that necessitate gene synthesis services,
contributing significantly to market growth.
Furthermore,
North America is at the forefront of technological advancements, including
automation and artificial intelligence in gene synthesis processes. This
technological edge enhances the efficiency and cost-effectiveness of gene
synthesis services, attracting customers from around the world. In addition,
the region benefits from a skilled workforce and a strong academic and research
infrastructure. North American universities and research institutions
consistently produce top-tier talent in the fields of genetics, genomics, and
molecular biology, further fueling the demand for gene synthesis expertise. Moreover,
North America's regulatory environment is conducive to biotechnology research
and commercialization, instilling confidence in investors and businesses. It
also encourages the responsible use of gene synthesis technologies. In
conclusion, North America's dominance in the gene synthesis market is a result
of its strong biotech sector, innovation ecosystem, technological leadership,
skilled workforce, favorable regulatory landscape, and its role as a global hub
for biotechnology research and development. These factors collectively position
North America as a leader in the gene synthesis industry.
Recent Developments
- In
June 2024, GenScript Biotech Corporation, a leading provider of gene synthesis
services, launched the GenScript FLASH Gene service, an ultra-fast sequence-to-plasmid
(S2P) solution. This service sets a new industry standard by delivering gene
constructs in just four business days at a flat-rate price of $89. Offering cloning,
plasmid preparation, and gene synthesis, it provides researchers and biotech
firms with a rapid, high-quality, and cost-effective solution.
- In
June 2023, Eurofins Genomics Blue Heron, a leader in advanced gene analysis,
introduced its in-vitro transcription (IVT) messenger RNA (mRNA) synthesis
service, set to launch on June 29, 2023. Designed to meet the needs of
researchers requiring fast turnaround times and high-quality, customized
monoclonal antibody (MAb) synthesis, this service provides a comprehensive
solution for genetic research and therapeutic development.
- In
August 2023, Illumina, a leading company in gene sequencing and synthesis,
introduced the NovaSeq X Plus sequencing system. This advanced system offers higher
throughput and accelerated sequencing speeds, enabling researchers to analyze
larger datasets more efficiently. The innovation is expected to drive increased
demand for gene synthesis services.
- In
2023, the Indian biotech startup Mapmygenome introduced an advanced gene
synthesis service designed to deliver customized DNA sequences for research and
clinical applications. This initiative aims to enhance the availability of gene
synthesis services in India while addressing the increasing demand from
research institutions and healthcare providers.
Key Market Players
- OriGene Technologies, Inc.
- Integrated DNA
Technologies, Inc.
- ProMab Biotechnologies,
Inc.
- Thermo Fisher Scientific,
Inc.
- ProteoGenix, Inc.
- Biomatik USA LLC
- Twist Bioscience
- Boster Biological
Technology
- Brooks Automation, Inc.
- Genscript Corporation
|
By Method
|
By Service
|
By Application
|
By End Use
|
By Region
|
- Solid-phase Synthesis
- Chip-based Synthesis
- PCR-based Enzyme Synthesis
|
- Antibody DNA Synthesis
- Viral DNA Synthesis
- Others
|
- Gene & Cell Therapy Development
- Vaccine Development
- Disease Diagnosis
- Others
|
- Biotechnology and Pharmaceutical Companies
- Academic and Government Research Institutes
- Contract Research Organizations
|
- North America
- Europe
- Asia Pacific
- South America
- Middle East & Africa
|
Report
Scope:
In
this report, the Global Gene Synthesis Market has been segmented into the
following categories, in addition to the industry trends which have also been
detailed below:
- Gene Synthesis Market, By Method:
o Solid-phase Synthesis
o Chip-based Synthesis
o PCR-based Enzyme Synthesis
- Gene Synthesis Market, By Service:
o
Antibody DNA Synthesis
o
Viral DNA Synthesis
o
Others
- Gene Synthesis Market, By Application:
o
Gene & Cell Therapy Development
o
Vaccine Development
o
Disease Diagnosis
o
Others
- Gene Synthesis Market, By End Use:
o
Biotechnology and Pharmaceutical Companies
o
Academic and Government Research Institutes
o
Contract Research Organizations
- Gene Synthesis Market, By Region:
o North America
§ United States
§ Canada
§ Mexico
o Europe
§ France
§ United Kingdom
§ Italy
§ Germany
§ Spain
o Asia-Pacific
§ China
§ India
§ Japan
§ Australia
§ South Korea
o South America
§ Brazil
§ Argentina
§ Colombia
o Middle East & Africa
§ South Africa
§ Saudi Arabia
§ UAE
Competitive
Landscape
Company
Profiles: Detailed
analysis of the major companies present in the Global Gene Synthesis Market.
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