NGS-Based RNA-Sequencing Market to Grow with a CAGR of 6.13% through 2029

Increasing Investments in Research and Development and supportive Stringent Regulatory Standard are the drivers for the Global NGS-Based RNA-Sequencing Market during the forecast period, 2025-2029

According to TechSci Research report, “NGS-Based RNA-Sequencing Market– Global Industry Size, Share, Trends, Competition Forecast & Opportunities, 2029F”, Global NGS-Based RNA-Sequencing Market was valued at USD 2.67 billion in 2023 and will see an impressive growth in the forecast period at a CAGR of 6.13% through 2029.

As the expenses associated with sequencing technologies decrease, Next-Generation Sequencing (NGS)-based RNA sequencing becomes more economically viable and accessible to a wider spectrum of researchers, laboratories, and institutions. This reduction in sequencing costs empowers academic researchers, small biotech companies, and clinical laboratories to undertake RNA sequencing experiments that were previously financially unfeasible.

The lowered cost of RNA sequencing allows researchers to expand the scale of their genomic research endeavors, conduct studies with larger sample sizes, and carry out more comprehensive analyses. Researchers can now afford to sequence numerous RNA samples from various tissues, cell types, experimental conditions, and patient cohorts, resulting in more extensive datasets and facilitating robust statistical analyses. Decreasing sequencing expenses also enable population-based studies and large-scale cohort initiatives aimed at unraveling the genetic underpinnings of complex diseases, population genetics, and personalized medicine. Researchers can sequence the RNA samples of thousands to millions of individuals, pinpoint disease-associated genetic variants, and investigate gene-environment interactions on a population level. Additionally, lower sequencing costs support longitudinal studies that track changes in gene expression patterns over time, disease progression, and responses to treatments.

RNA-sequencing experiments involve multiple steps, including RNA extraction, library preparation, sequencing, and data analysis. There are numerous protocols and kits available for each step, leading to variability in experimental procedures across different laboratories and studies. Standardizing experimental protocols and reagents is challenging due to differences in sample types, species, RNA isolation methods, library preparation techniques, and sequencing platforms. The analysis of RNA-sequencing data requires the use of bioinformatics tools and computational algorithms for read alignment, transcript quantification, differential expression analysis, pathway enrichment analysis, and data visualization. However, there is a lack of standardized data analysis pipelines, leading to variability in analysis methodologies and results across different studies and research groups. Standardizing data analysis pipelines and benchmarking analysis workflows against reference datasets can help improve the reproducibility and reliability of RNA-sequencing results. Ensuring the quality and integrity of RNA-sequencing data is essential for obtaining accurate and reliable results. Quality control metrics assess various aspects of sequencing data, including read quality, sequencing depth, mapping efficiency, transcript coverage, and gene expression variability. However, there is a lack of consensus on standardized quality control metrics and thresholds for RNA-sequencing experiments, making it challenging to assess data quality and compare results across different studies.

                                                                                            

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The Global NGS-Based RNA-Sequencing Market is segmented into Product and Services, Technology, Application,  End User, regional distribution, and company.

Based on its Application, The Small RNA Sequencing segment is projected to experience rapid growth in the Global NGS-Based RNA-Sequencing Market during the forecast period. Small RNA sequencing enables the profiling and analysis of non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and other regulatory RNA molecules. These non-coding RNAs play crucial roles in gene regulation, development, and disease processes. As researchers delve deeper into understanding the functional significance of non-coding RNAs, the demand for small RNA sequencing technologies increases. Small RNA sequencing is widely used in biomedical research to study various biological processes, including development, differentiation, disease progression, and response to therapy. Researchers leverage small RNA sequencing to identify biomarkers, understand disease mechanisms, and discover potential therapeutic targets. The versatility of small RNA sequencing across different research domains drives its adoption and fuels market growth. Continuous advancements in sequencing technologies, bioinformatics tools, and library preparation methods have enhanced the accuracy, sensitivity, and throughput of small RNA sequencing assays. These technological improvements enable researchers to efficiently profile small RNA populations from diverse biological samples, including tissues, cells, biofluids, and extracellular vesicles. As sequencing platforms become more accessible and cost-effective, small RNA sequencing becomes more widely adopted across research institutions and laboratories. Small RNA sequencing holds promise for clinical applications, including diagnostic biomarker discovery, disease monitoring, and personalized medicine. As researchers uncover the diagnostic and prognostic value of small RNA signatures in various diseases, there is growing interest in translating these findings into clinical practice. The potential for small RNA sequencing to inform clinical decision-making drives investment and growth in this segment of the NGS-based RNA sequencing market.

Based on region, North America is dominating the market.  North America, particularly the United States, stands out as a prominent center for biomedical research and innovation, hosting prestigious universities, research institutions, and biotechnology firms. This concentration of expertise and resources fuels the advancement and adoption of next-generation sequencing (NGS) technologies, notably RNA sequencing. The region boasts a vibrant biotechnology and pharmaceutical sector, comprising established companies and startups alike. These entities heavily invest in research and development (R&D) across various domains, including drug discovery, diagnostics, and personalized medicine, all of which rely extensively on RNA sequencing technologies. The demand for NGS-based RNA sequencing solutions is propelled by the imperative to decipher gene expression patterns, pinpoint therapeutic targets, and pioneer new treatments for diseases.

 

Major companies operating in Global NGS-Based RNA-Sequencing Market are:

• Illumina Inc.
• Thermo Fischer Scientific Inc.
• Oxford Nanopore Technologies plc
• Agilent Technologies, Inc.
• PerkinElmer Inc
• QIAGEN N.V.
• Eurofins Scientific SE
• F. Hoffmann-La Roche Ltd
• Takara Bio Inc.
• Azenta Life Sciences

 

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“NGS-based RNA-sequencing market is characterized by rapid technological advancements, increasing adoption across diverse research areas, and growing applications in clinical research and diagnostics. Major progressions shaping the NGS-based RNA-sequencing market includes the integration of multi-omics data, the emergence of single-cell RNA sequencing (scRNA-seq) technologies, and the focus on data analysis and interpretation", said Mr. Karan Chechi, Research Director of TechSci Research, a research-based Global management consulting firm.

“NGS-Based RNA-Sequencing Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, Segmented By Product and Services (RNA Sequencing Platforms and Consumables, Sample Preparation Products, RNA Sequencing Services, Data Analysis, Storage and Management), By Technology (Sequencing By Synthesis, Ion Semiconductor Sequencing, Single-Molecule Real-Time Sequencing, Nanopore Sequencing), By Application (Expression Profiling Analysis, Small RNA Sequencing, De Novo Transcriptome Assembly, Variant Calling and Transcriptome Epigenetics), By End User (Research and Academia, Hospitals and Clinics, Pharmaceutical and Biotechnology Companies, Others), By Region, and By Competition, 2019-2029F”, has evaluated the future growth potential of Global NGS-Based RNA-Sequencing Market and provides statistics & information on market size, structure and future market growth. The report intends to provide cutting-edge market intelligence and help decision makers take sound investment decisions. Besides, the report also identifies and analyzes the emerging trends along with essential drivers, challenges, and opportunities in Global NGS-Based RNA-Sequencing Market.

 

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