Zinc Finger Nuclease Technology Market to grow with a CAGR of 19.20%
Increasing
healthcare infrastructure and a supportive regulatory environment are the major
drivers for the Global Zinc Finger Nuclease Technology Market.
According
to TechSci Research report, “Global Zinc Finger Nuclease Technology Market Industry
Size, Share, Trends, Competition, Opportunity and Forecast, 2018-2028”, Global Zinc Finger Nuclease
Technology Market has valued at USD 728.50 million in 2022 and is anticipated
to witness an impressive growth in the forecast period with a CAGR of 19.20%
through 2028. This can be due to
collaborations and partnerships among leading companies with a diverse approach
to merge the expertise of individual companies and to strengthen their position
in the market.
The
potential for disease modeling has indeed driven the demand for Zinc Finger
Nuclease (ZFN) Technology, particularly in the field of biomedical research and
drug discovery. Disease modeling involves the creation of models that mimic the
genetic, cellular, and physiological aspects of human diseases, allowing
researchers to study the disease's mechanisms, test potential therapies, and
gain insights into disease progression. ZFNs provide a level of precision in
genome editing that is well-suited for creating disease models. Researchers can
use ZFNs to introduce specific genetic mutations or alterations that are
associated with diseases, replicating the genetic basis of the condition
accurately. ZFNs are particularly valuable for modeling genetic diseases caused
by specific mutations. By introducing these mutations into the genome of model
organisms (e.g., mice or cell lines), researchers can study disease mechanisms
and test potential therapeutic interventions. Disease modeling with ZFNs is
essential for functional genomics research. Researchers can assess the
functional consequences of specific genetic mutations and gain a deeper
understanding of how these mutations contribute to disease pathology.
Attached
to the zinc finger proteins is a nuclease domain, typically derived from the
FokI endonuclease. The nuclease domain can cut DNA at a specific location,
creating a double-strand break (DSB) in the DNA molecule. ZFN Technology was a
pioneering method in genome editing, it has faced competition from newer and
more straightforward technologies like CRISPR-Cas9. CRISPR-Cas9 has become the
dominant genome editing tool due to its simplicity and versatility. But ZFNs
are still used in specific applications where their unique capabilities, such
as high specificity, may offer advantages.
In
March 2023, Nuclease 46L (N046L), a novel enzyme developed by enzyme experts at
Biocatalysts Ltd., has been made available for the breakdown of various nucleic
acids from a variety of sources. It was created primarily as a low-cost method
to get rid of DNA in a variety of biotechnology applications. Technologies for
microbiological (or precise) fermentation allow for the cost-effective
synthesis of certain goods, like enzymes and proteins, at enormous commercial
sizes. Due to the scalability of microbial fermentation and the need to
commercialize environmentally friendly production techniques, additional
downstream processing, such as the need to remove nucleic acid residues, is now
necessary.
Off-target effects have been a significant
challenge in the Global Zinc Finger Nuclease (ZFN) Technology Market, as they
can lead to unintended genetic modifications and pose safety concerns. Off-target
effects occur when ZFNs, or other genome editing tools, make unintended
alterations to DNA sequences in the genome, rather than modifying the intended
target gene. These off-target changes can result from the ZFNs recognizing and
cleaving DNA sequences that closely resemble the target site but are not
identical. Off-target effects can lead to genetic mutations that may have
detrimental consequences, including the development of diseases or other
undesirable outcomes. Off-target effects can introduce unintended genetic
changes that may be harmful to the organism or individual. In therapeutic
applications, such as gene therapy, ensuring the safety of the patient is
paramount. Unintended modifications may lead to unexpected health risks.
Browse over XX market data Figures and spread through 110 Pages and an
in-depth TOC on "Zinc Finger Nuclease Technology Market.”
Global Zinc Finger Nuclease Technology Market segmentation
is based on
Type, End User, and Region. Based on
Type, Global Zinc Finger Nuclease Technology Market is segmented into Animal
Genetic Engineering, Cell Line Engineering, Plant Genetic Engineering. Plant
Genetic Engineering, also known as plant genetic modification or plant
biotechnology, is a scientific and technological process that involves the
deliberate alteration of a plant's genetic material to introduce or enhance
specific traits or characteristics. This genetic manipulation allows scientists
and plant breeders to create plants with desired traits, such as improved crop
yields, resistance to pests or diseases, enhanced nutritional content, or
tolerance to environmental stresses.
Based on Region, North America dominated the Global Zinc Finger Nuclease
Technology Market. North American institutions and companies have been
active in collaborating with each other and forming partnerships with global
players in the field. These collaborations have accelerated research and
development efforts and facilitated knowledge sharing. Many key patents related
to genome editing technologies, including ZFNs, were initially granted to
researchers and institutions in North America. These patents have influenced
the competitive landscape and licensing agreements in the industry. North
America has a well-established healthcare infrastructure and regulatory
framework for clinical trials. This has enabled companies to conduct clinical
trials for ZFN-based therapies more efficiently, paving the way for potential
commercialization.
Asia-pacific region to fastest growth in
the Global Zinc Finger Nuclease Technology Market. The Asia-Pacific region is
home to a significant portion of the world's population, including some of the
most populous countries like China and India. This large and diverse population
presents a substantial market for biotechnology and healthcare, including
genome editing technologies like ZFNs. Many countries in the Asia-Pacific
region have been investing in healthcare infrastructure development, including
research and clinical facilities. This improved infrastructure provides a
conducive environment for the advancement and adoption of cutting-edge
technologies like ZFNs. The region has seen increased investment in research
and development, including biotechnology and life sciences. Academic
institutions, research centers, and biotechnology companies in the Asia-Pacific
are actively engaged in genome editing research and applications.
Some
of the major companies operating in the Global
Zinc Finger Nuclease Technology Market include:
- Applied
Biological Materials, Inc.
- Caribou
Biosciences, Inc.
- Cellectis,
Inc.
- GenScript
Biotech Corporation
- Gilead
Sciences, Inc.
- Horizon
Discovery Group, PLC
- Intellia
Therapeutics
- Merck
KGaA
- OriGene
Technologies, Inc
- Thermo
Fisher Scientific Inc.
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“Certain areas, particularly in
North America, are projected to exert significant demand for Zinc Finger
Nuclease Technology. The growth in the competitive landscape and the presence
of well-established companies in the market, committed to enhance the overall
wellbeing of people each year, are expected to contribute to a remarkable
growth of the Global Zinc Finger Nuclease Technology Market in the forecast
period," said Mr. Karan Chechi, Research Director with TechSci Research, a
research-based Global management consulting firm.
Zinc Finger Nuclease Technology Market –
Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented
by Type (Animal Genetic Engineering, Cell Line Engineering, Plant Genetic
Engineering), by end user (Biotechnology and Pharmaceutical Companies, Academic
& Research Institutions, Hospitals & Clinics, Others), by region, and
Competition evaluated the future growth
potential of Global Zinc Finger Nuclease Technology Market and provides
statistics & information on market size, structure, and future market
growth. The report intends to provide innovative market intelligence and help
decision makers take sound investment decisions. Besides, the report also
identifies and analyzes the emerging trends along with essential drivers,
challenges, and opportunities in Global Zinc Finger Nuclease Technology Market.
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